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14 pages, 1535 KiB  
Article
飞艇168开奖视频直播_中国福利 Directional Differences in Thematic Maps of Soil Chemical Attributes with Geometric Anisotropy
Stats 2024, 7(1), 65-78; https://doi.org/10.3390/stats7010005 (registering DOI) - 16 Jan 2024
Abstract
查询开奖官网记录结果计划-168网幸运飞行艇手机版直播现场 of soil chemical attributes, the process is considered anisotropic when the spatial dependence structure differs in relation to the direction. Anisotropy is a characteristic that influences the accuracy of the thematic maps that represent the spatial [...] Read more.
In the study of the spatial variability of soil chemical attributes, the process is considered anisotropic when the spatial dependence structure differs in relation to the direction. Anisotropy is a characteristic that influences the accuracy of the thematic maps that represent the spatial variability of the phenomenon. Therefore, the linear anisotropic Gaussian spatial model is important for spatial data that present anisotropy, and incorporating this as an intrinsic characteristic of the process that describes the spatial dependence structure improves the accuracy of the spatial estimation of the values of a georeferenced variable in unsampled locations. This work aimed at quantifying the directional differences existing in the thematic map of georeferenced variables when incorporating or not incorporating anisotropy into the spatial dependence structure through directional spatial autocorrelation. For simulated data and soil chemical properties (carbon, calcium and potassium), the Moran directional index was calculated, considering the predicted values at unsampled locations, and taking into account estimated isotropic and anisotropic geostatistical models. The directional spatial autocorrelation was effective in evidencing the directional difference between thematic maps elaborated with estimated isotropic and anisotropic geostatistical models. This measure evidenced the existence of an elliptical format of the subregions presented by thematic maps in the direction of anisotropy that indicated a greater spatial continuity for greater distances between pairs of points. Full article
(This article belongs to the Section Statistical Methods)
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21 pages, 4285 KiB  
Article
Stacking Ensemble-Based Machine Learning Model for Predicting Deterioration Components of Steel W-Section Beams
Buildings 2024, 14(1), 240; https://doi.org/10.3390/buildings14010240 (registering DOI) - 16 Jan 2024
Abstract
The collapse evaluation of the structural systems under seismic loading necessitates identifying and quantifying deterioration components (DCs). In the case of steel w-section beams (SWSB), three distinct types of DCs have been derived. These deterioration components for steel beams comprise the following: pre-capping [...] Read more.
The collapse evaluation of the structural systems under seismic loading necessitates identifying and quantifying deterioration components (DCs). In the case of steel w-section beams (SWSB), three distinct types of DCs have been derived. These deterioration components for steel beams comprise the following: pre-capping plastic rotation (θp), post-capping plastic rotation (θpc), and cumulative rotation capacity (Λ). The primary objective of this research is to employ a machine learning (ML) model for accurate determination of these deterioration components. The stacking model is a powerful combination of meta-learners, which is used for better learning and performance of base learners. The base learners consist of AdaBoost, Random Forest (RF), and XGBoost. Among various machine learning algorithms, the stacking model exhibited superior functioning. The evaluation metrics of the stacking model were as follows: R2 = 0.9 and RMSE = 0.003 for θp, R2 = 0.97 and RMSE = 0.012 for θpc, and R2 = 0.98 and RMSE = 0.09 for Λ. The significance of input variables, specifically the web-depth-over-web-thickness ratio (h/tw) and the flange width-to-thickness ratio (bf/2tf), in determining the deterioration components was assessed using the Shapley Additive Explanations model. These parameters emerged as the most crucial factors in the evaluation. Full article
(This article belongs to the Special Issue Mechanical Performance of Steel and Composite Beams)
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23 pages, 2812 KiB  
Article
Interpreting the Interaction of Genotype with Environmental Factors in Barley Using Partial Least Squares Regression Model
Agronomy 2024, 14(1), 194; https://doi.org/10.3390/agronomy14010194 (registering DOI) - 16 Jan 2024
Abstract
Genotype by environment interaction (GEI) is a complex problem that complicates the barley selection and breeding process. The knowledge of the relationship between cereal phenology and climatic data is important for understanding GEI and the physiological pathways responsible for the interaction effect. The [...] Read more.
Genotype by environment interaction (GEI) is a complex problem that complicates the barley selection and breeding process. The knowledge of the relationship between cereal phenology and climatic data is important for understanding GEI and the physiological pathways responsible for the interaction effect. The grain yield of twenty winter barley genotypes in six environments was observed. Factors influencing the variability were analyzed using a linear mixed model. The partial least squares regression (PLSR) model was applied to determine the most relevant environmental variables in certain stages of development that explained GEI effects. Biplot with environmental variables explained 43.7% of the GEI. The barley was generally the most sensitive to the environmental conditions (relative humidity, maximum temperature and its variation, sun hours, and precipitation) during the anthesis and filling stage (May) which caused GEI. Temperature variables did not show significance only in the vegetative phase. Different genotypes responded differently to environmental factors. Genotypes NS-525, NS-589, and J-103 were highlighted as widely adaptable, and Zaječar was a suitable and reliable location for yield testing. The GEI information presented in this paper can be useful in traditional plant breeding and future breeding programs through molecular research of crop developmental genes and examination of physiological processes in two-row barley. Full article
(This article belongs to the Special Issue Crop Biology and Breeding under Environmental Stress)
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13 pages, 3275 KiB  
Article
LeGO-LOAM-FN: An Improved Simultaneous Localization and Mapping Method Fusing LeGO-LOAM, Faster_GICP and NDT in Complex Orchard Environments
Sensors 2024, 24(2), 551; https://doi.org/10.3390/s24020551 (registering DOI) - 16 Jan 2024
Abstract
To solve the problem of cumulative errors when robots build maps in complex orchard environments due to their large scene size, similar features, and unstable motion, this study proposes a loopback registration algorithm based on the fusion of Faster Generalized Iterative Closest Point [...] Read more.
To solve the problem of cumulative errors when robots build maps in complex orchard environments due to their large scene size, similar features, and unstable motion, this study proposes a loopback registration algorithm based on the fusion of Faster Generalized Iterative Closest Point (Faster_GICP) and Normal Distributions Transform (NDT). First, the algorithm creates a K-Dimensional tree (KD-Tree) structure to eliminate the dynamic obstacle point clouds. Then, the method uses a two-step point filter to reduce the number of feature points of the current frame used for matching and the number of data used for optimization. It also calculates the matching degree of normal distribution probability by meshing the point cloud, and optimizes the precision registration using the Hessian matrix method. In the complex orchard environment with multiple loopback events, the root mean square error and standard deviation of the trajectory of the LeGO-LOAM-FN algorithm are 0.45 m and 0.26 m which are 67% and 73% higher than those of the loopback registration algorithm in the Lightweight and Ground-Optimized LiDAR Odometry and Mapping on Variable Terrain (LeGO-LOAM), respectively. The study proves that this method effectively reduces the influence of the cumulative error, and provides technical support for intelligent operation in the orchard environment. Full article
(This article belongs to the Section Smart Agriculture)
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20 pages, 4067 KiB  
Article
Research on Lateral Safety Spacing for Fusion Operation Based on Unmanned and Manned Aircraft-Event Modeling
Sensors 2024, 24(2), 553; https://doi.org/10.3390/s24020553 (registering DOI) - 16 Jan 2024
Abstract
With the rapid development of unmanned aerial vehicle technology and its increasing application across various fields, current airspace resources are insufficient for unmanned aerial vehicles’ needs. This paper, taking Zigong General Aviation Airport in Sichuan as a case study, explores the lateral safety [...] Read more.
With the rapid development of unmanned aerial vehicle technology and its increasing application across various fields, current airspace resources are insufficient for unmanned aerial vehicles’ needs. This paper, taking Zigong General Aviation Airport in Sichuan as a case study, explores the lateral safety spacing in a mixed operation mode of unmanned aerial vehicles and manned aircraft. Currently, there are no standardized regulations for the safe spacing of the fusion operation of unmanned and manned aircraft. Theoretical research is essential to provide a reference for actual operations. It introduces the UM-Event (unmanned and manned aircraft-event) collision risk model, an adaptation of the Event collision risk model, considering factors like communication, navigation, surveillance performance, human factors, collision avoidance equipment performance, and meteorology. Safety spacing was determined via simulation experiments and actual data analysis, adhering to the target safety level (TSL). Findings indicate that surveillance performance has a minor impact on safety spacing, while communication and navigation significantly influence it. The safety spacing, influenced solely by CNS (communication performance, navigation performance, surveillance performance) and combined factors, increased from 4.42 to 4.47 nautical miles. These results offer theoretical guidance for unmanned aerial vehicle safety in non-segregated airspace. Full article
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14 pages, 2651 KiB  
Article
168体彩飞艇官网查询记录,168视频,幸运彩飞艇直播在线查询 Exploring MicroRNAs Associated with Pomegranate Pistil Development: An Identification and Analysis Study
Horticulturae 2024, 10(1), 85; https://doi.org/10.3390/horticulturae10010085 (registering DOI) - 16 Jan 2024
Abstract
The interaction between miRNAs (在线幸运飞行艇结果号码记录) and target genes plays an important role in plant pistil development. MiRNAs related to pistils were explored in pomegranate. The differentially expressed miRNAs were screened at different developmental stages of pomegranate pistils, and their target differentially expressed mRNAs [...] Read more.
The interaction between miRNAs (在线幸运飞行艇结果号码记录) and target genes plays an important role in plant pistil development. MiRNAs related to pistils were explored in pomegranate. The differentially expressed miRNAs were screened at different developmental stages of pomegranate pistils, and their target differentially expressed mRNAs were further identified to clarify the regulatory effect of miRNAs on pistil development. In our study, 61 conserved miRNAs were identified in 30 families, including miR395, miR394, miR393, miR161, miR162, and miR168. Among them, miR156, miR157, miR159, miR160, miR164, miR165, miR166, miR167, miR169, and miR172 were involved in the development of flower organs. Eight miRNAs were randomly selected and verified for qRT-PCR analysis. The result analysis indicated that miR160, miR164, and miR172 might be positive factors in the regulation of pomegranate pistil development. MiR156 and miR166 might be involved in regulation of pomegranate pistil development as negative factors. Full article
(This article belongs to the Special Issue Research on Pomegranate Germplasm, Breeding, Genetics and Multiomics)
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15 pages, 6721 KiB  
Article
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Foods 2024, 13(2), 276; https://doi.org/10.3390/foods13020276 (registering DOI) - 16 Jan 2024
Abstract
The liver is critical in alcohol metabolism, and excessive consumption heightens the risk of hepatic damage, potentially escalating to hepatitis and cirrhosis. Jiuzao, a by-product of Baijiu production, contains a rich concentration of naturally active polysaccharides known for their antioxidative properties. This [...] Read more.
The liver is critical in alcohol metabolism, and excessive consumption heightens the risk of hepatic damage, potentially escalating to hepatitis and cirrhosis. Jiuzao, a by-product of Baijiu production, contains a rich concentration of naturally active polysaccharides known for their antioxidative properties. This study investigated the influence of Laowuzeng Jiuzao polysaccharide (LJP) on the development of ethanol-induced alcoholic fatty liver. Zebrafish larvae served as the model organisms for examining the LJPs hepatic impact via liver phenotypic and biochemical assays. Additionally, this study evaluated the LJPs effects on gene expression associated with alcoholic fatty liver and the composition of the intestinal microbiota through transcriptomic and 16 S rRNA gene sequencing analyses, respectively. Our findings revealed that LJP markedly mitigated morphological liver damage and reduced oxidative stress and lipid peroxidation in larvae. Transcriptome data indicated that LJP ameliorated hepatic fat accumulation and liver injury by enhancing gene expression involved in alcohol and lipid metabolism. Furthermore, LJP modulated the development of alcoholic fatty liver by altering the prevalence of intestinal Actinobacteriota and Firmicutes, specifically augmenting Acinetobacter while diminishing Chryseobacterium levels. Ultimately, LJP mitigated alcohol-induced hepatic injury by modulating gene expression related to ethanol metabolism, lipid metabolism, and inflammation and by orchestrating alterations in the intestinal microbiota. Full article
(This article belongs to the Section Food Microbiology)
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13 pages, 10016 KiB  
Article
Evaluating Microbial Biofertilizers for Root Colonization Potential in Narra (Pterocarpus indicus Willd.) and Their Efficacy in Heavy Metal Remediation
Forests 2024, 15(1), 180; https://doi.org/10.3390/f15010180 (registering DOI) - 16 Jan 2024
Abstract
Bioremediation technology, another strategy known for restoring degraded environments, utilizes beneficial microorganisms, including arbuscular mycorrhizal fungi (AMF) and nitrogen-fixing bacteria (NFB). Despite its potential, the biological processes of these microorganisms in contaminated sites remain poorly understood, hindering effective pollutant toxicity reduction. Establishing a [...] Read more.
Bioremediation technology, another strategy known for restoring degraded environments, utilizes beneficial microorganisms, including arbuscular mycorrhizal fungi (AMF) and nitrogen-fixing bacteria (NFB). Despite its potential, the biological processes of these microorganisms in contaminated sites remain poorly understood, hindering effective pollutant toxicity reduction. Establishing a connection between plant root systems and these microorganisms is crucial for enabling plant survival in heavy metal-contaminated soils. Narra (Pterocarpus indicus Willd.), a leguminous plant, typically associates with symbiotic nitrogen-fixing bacteria, forming nodules in the roots. Additionally, Narra forms a symbiotic relationship with AMF, phosphorus-fixing microbes, making it an ideal tree species for rehabilitating mined-out areas. In this study, five microbial biofertilizers, namely: MYKORICH®, MYKOVAM®, newMYC, newNFB, and combined newMYC+newNFB, plus a control were used to test their root colonization potential on Narra seedlings grown in nickel (Ni) and gold (Au) mined-out soils collected from Taganito Mining Corporation (TMC) and Manila Mining Corporation (MMC) in Claver and Placer, Surigao del Norte, Philippines, respectively. The results showed that newMYC had the highest root colonization in Ni mined-out soil, while MYKORICH® excelled in Au mined-out soil. The AMF spore count was highest in MYKORICH® for Ni mined-out soil and newMYC in Au mined-out soil. NFB colonization was highest in newMYC-treated seedlings for Ni mined-out soil and combined newMYC+newNFB for Au mined-out soil. The microbial biofertilizers utilized in this research, such as MY-KORICH®, MYKOVAM, newMYC, newNFB, and combined newNFB and newMYC, naturally occur in the environment and can be easily extracted. This cost-effective characteristic provides an advantage for mining companies seeking treatments for soil amelioration to rehabilitate mined-out areas. Full article
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17 pages, 1930 KiB  
Article
PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids
Nutrients 2024, 16(2), 261; https://doi.org/10.3390/nu16020261 (registering DOI) - 16 Jan 2024
Abstract
The GG genotype of the Patatin-like phosphatase domain-containing 3 (PNPLA3), dietary fat, short-chain fatty acids (SCFA) and branched-chain amino acids (BCAA) are linked with non-alcoholic fatty liver disease. We studied the impact of the quality of dietary fat on plasma (p) [...] Read more.
The GG genotype of the Patatin-like phosphatase domain-containing 3 (PNPLA3), dietary fat, short-chain fatty acids (SCFA) and branched-chain amino acids (BCAA) are linked with non-alcoholic fatty liver disease. We studied the impact of the quality of dietary fat on plasma (p) and fecal (f) SCFA and p-BCAA in men homozygous for the PNPLA3 rs738409 variant (I148M). Eighty-eight randomly assigned men (age 67.8 ± 4.3 years, body mass index 27.1 ± 2.5 kg/m2) participated in a 12-week diet intervention. The recommended diet (RD) group followed the National and Nordic nutrition recommendations for fat intake. The average diet (AD) group followed the average fat intake in Finland. The intervention resulted in a decrease in total p-SCFAs and iso-butyric acid in the RD group (p = 0.041 and p =0.002). Valeric acid (p-VA) increased in participants with the GG genotype regardless of the diet (RD, 3.6 ± 0.6 to 7.0 ± 0.6 µmol/g, p = 0.005 and AD, 3.8 ± 0.3 to 9.7 ± 8.5 µmol/g, p = 0.015). Also, genotype relation to p-VA was seen statistically significantly in the RD group (CC: 3.7 ± 0.4 to 4.2 ± 1.7 µmol/g and GG: 3.6 ± 0.6 to 7.0 ± 0.6 µmol/g, p = 0.0026 for time and p = 0.004 for time and genotype). P-VA, unlike any other SCFA, correlated positively with plasma gamma-glutamyl transferase (r = 0.240, p = 0.025). Total p-BCAAs concentration changed in the AD group comparing PNPLA3 CC and GG genotypes (CC: 612 ± 184 to 532 ± 149 µmol/g and GG: 587 ± 182 to 590 ± 130 µmol/g, p = 0.015 for time). Valine decreased in the RD group (p = 0.009), and leucine decreased in the AD group (p = 0.043). RD decreased total fecal SCFA, acetic acid (f-AA), and butyric acid (f-BA) in those with CC genotype (p = 0.006, 0.013 and 0.005, respectively). Our results suggest that the PNPLA3 genotype modifies the effect of dietary fat modification for p-VA, total f-SCFA, f-AA and f-BA, and total p-BCAA. Full article
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10 pages, 1827 KiB  
Data Descriptor
Proteomic and Metabolomic Analyses of the Blood Samples of Highly Trained Athletes
Data 2024, 9(1), 15; https://doi.org/10.3390/data9010015 (registering DOI) - 16 Jan 2024
Abstract
High exercise loading causes intricate and ambiguous proteomic and metabolic changes. This study aims to describe the dataset on protein and metabolite contents in plasma samples collected from highly trained athletes across different sports disciplines. The proteomic and metabolomic analyses of the plasma [...] Read more.
High exercise loading causes intricate and ambiguous proteomic and metabolic changes. This study aims to describe the dataset on protein and metabolite contents in plasma samples collected from highly trained athletes across different sports disciplines. The proteomic and metabolomic analyses of the plasma samples of highly trained athletes engaged in sports disciplines of different intensities were carried out using HPLC-MS/MS. The results are reported as two datasets (proteomic data in a derived mgf-file and metabolomic data in processed format), each containing the findings obtained by analyzing 93 mass spectra. Variations in the protein and metabolite contents of the biological samples are observed, depending on the intensity of training load for different sports disciplines. Mass spectrometric proteomic and metabolomic studies can be used for classifying different athlete phenotypes according to the intensity of sports discipline and for the assessment of the efficiency of the recovery period. Full article
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19 pages, 9408 KiB  
Article
Numerical Study of Bearing Strength of Infilled Concrete in Large Diameter CFST Column Reinforced by Shear Stoppers
Designs 2024, 8(1), 9; https://doi.org/10.3390/designs8010009 (registering DOI) - 16 Jan 2024
Abstract
Ensuring an adequate bond between the steel tube and infilled concrete interface plays an essential role in achieving composite action for concrete-filled steel tubular (CFST) columns. Thus, this study proposes a new type of large diameter CFST column where the steel tube is [...] Read more.
Ensuring an adequate bond between the steel tube and infilled concrete interface plays an essential role in achieving composite action for concrete-filled steel tubular (CFST) columns. Thus, this study proposes a new type of large diameter CFST column where the steel tube is reinforced by shear stoppers. The bearing strength of the infilled concrete is the decisive factor in evaluating the overall working efficiency between infilled concrete and steel tube. In this paper, we use nonlinear finite element analysis (NFEA) to investigate the bearing strength of the infilled concrete concerning the ratio of the steel tube’s diameter to its thickness (D/t), the number of shear stoppers N, the height of the shear stopper hb, and the concrete compressive strength (CCS) fc. Our results show that the influencing factors on the bearing strength of the infilled concrete were arranged in descending order as follows: the number of shear stoppers, the height of shear stopper, the CCS, and the D/t ratio. We also analyze and highlight some significant parameters related to the bearing strength of infilled concrete. Full article
(This article belongs to the Topic Resilient Civil Infrastructure)
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14 pages, 224 KiB  
Article
The Evolution of Warfare and Weapons in Japan, 792–1392
Histories 2024, 4(1), 24-37; https://doi.org/10.3390/histories4010002 (registering DOI) - 16 Jan 2024
Abstract
The fearsome Japanese samurai, a legendary figure whose primary attribute was loyalty or honor, needs no introduction. He is strongly associated with the equally famous katana. The popular image of the samurai probably would appear wearing armor but certainly does not carry a [...] Read more.
The fearsome Japanese samurai, a legendary figure whose primary attribute was loyalty or honor, needs no introduction. He is strongly associated with the equally famous katana. The popular image of the samurai probably would appear wearing armor but certainly does not carry a shield. This figure, many assume, must have dominated medieval Japan. Yet is this samurai image accurate? Can it withstand sustained scrutiny? What was Japanese warfare really like 1000 years ago? In this article, I evaluate the key sources on medieval warfare in Japan, identifying the contributions of each and pointing out some methodological problems they face. The most prominent casualty of this synthetic analysis is the pop culture image of the heroic and honorable sword-wielding samurai. Full article
12 pages, 2468 KiB  
Article
Study on the Frying Performance Evaluation of Refined Soybean Oil after PLC Enzymatic Degumming
Foods 2024, 13(2), 275; https://doi.org/10.3390/foods13020275 (registering DOI) - 16 Jan 2024
Abstract
It is known that phospholipase C (PLC) enzymatic degumming can hydrolyze phospholipids into diacylglycerol (DAG), which improves the efficiency of oil processing. However, it is unclear whether the presence of DAG and the use of enzymes affect the performance of the oil. This [...] Read more.
It is known that phospholipase C (PLC) enzymatic degumming can hydrolyze phospholipids into diacylglycerol (DAG), which improves the efficiency of oil processing. However, it is unclear whether the presence of DAG and the use of enzymes affect the performance of the oil. This paper evaluated the frying performance of PLC-degummed refined soybean oil. Following the chicken wings and potato chips frying trials, results revealed that after 30 cycles of frying, free fatty acid (FFA) levels were 0.22% and 0.21%, with total polar compounds (TPC) at 23.75% and 24.00%, and peroxide value (PV) levels were 5.90 meq/kg and 6.45 meq/kg, respectively. Overall, PLC-degummed refined soybean oil showed almost the same frying properties as traditional water-degummed refined oil in terms of FFA, PV, TPC, polymer content, viscosity, color, foaming of frying oils, and appearance of foods. Moreover, FFA, TPC, polymer content, foaming, and color showed significant positive correlations with each other (p < 0.05) in soybean oil intermittent frying processing. Full article
(This article belongs to the Special Issue Advanced Researches on Functional Lipids)
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13 pages, 1720 KiB  
Article
幸运飞行艇开奖号码查询+168飞艇全国开奖历史记录-官方开奖记录计划 In Vivo and In Vitro Pro-Fibrotic Response of Lung-Resident Mesenchymal Stem Cells from Patients with Idiopathic Pulmonary Fibrosis
Cells 2024, 13(2), 160; https://doi.org/10.3390/cells13020160 (registering DOI) - 16 Jan 2024
Abstract
Lung-resident mesenchymal stem cells (LR-MSC) 168新飞艇视频开奖官网结果 (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC in IPF patients present senescence-related features. It is unclear how they respond to a profibrotic environment. Here, we investigated the [...] Read more.
Lung-resident mesenchymal stem cells (LR-MSC) 168新飞艇视频开奖官网结果 (IPF) by differentiating into myofibroblasts. On the other hand, LR-MSC in IPF patients present senescence-related features. It is unclear how they respond to a profibrotic environment. Here, we investigated the profibrotic response of LR-MSC isolated from IPF and control (CON) patients. LR-MSC were inoculated in mice 48 h after bleomycin (BLM) instillation to analyze their contribution to lung damage. In vitro, LR-MSC were exposed to TGFβ. Mice inoculated with IPF LR-MSC exhibited worse maintenance of their body weight. The instillation of either IPF or CON LR-MSC sustained BLM-induced histological lung damage, bronchoalveolar lavage fluid cell count, and the expression of the myofibroblast marker, extracellular matrix (ECM) proteins, and proinflammatory cytokines in the lungs. In vitro, IPF LR-MSC displayed higher basal protein levels of aSMA and fibronectin than CON LR-MSC. However, the TGFβ response in the expression of TGFβ, aSMA, and ECM genes was attenuated in IPF LR-MSC. In conclusion, IPF LR-MSC have acquired myofibroblastic features, but their capacity to further respond to profibrotic stimuli seems to be attenuated. In an advanced stage of the disease, LR-MSC may participate in disease progression owing to their limited ability to repair epithelial damage. Full article
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26 pages, 3827 KiB  
Review
Regulation, Biosynthesis, and Extraction of Bacillus-Derived Lipopeptides and Its Implications in Biological Control of Phytopathogens
Stresses 2024, 4(1), 107-132; https://doi.org/10.3390/stresses4010007 (registering DOI) - 16 Jan 2024
Abstract
In recent years, the adoption of sustainable pest management strategies has increased interest in the utilization of biopesticides, with a focus on harnessing beneficial microorganisms. Among these, lipopeptides, such as surfactins, iturins, and fengycins produced by the genus Bacillus, have gained significant [...] Read more.
In recent years, the adoption of sustainable pest management strategies has increased interest in the utilization of biopesticides, with a focus on harnessing beneficial microorganisms. Among these, lipopeptides, such as surfactins, iturins, and fengycins produced by the genus Bacillus, have gained significant attention due to their multifaceted biocontrol mechanisms and wide-ranging inhibitory effects. This review aims to address the regulation, biosynthesis, and production of three main lipopeptide families secreted by the genus Bacillus, as well as the identification and quantification analysis used to date, through the omic tools approach. The three families have been identified as key contributors to the biocontrol abilities of these bacteria, with their broad-spectrum activity making them valuable tools in integrated pest management approaches that aim to reduce reliance on chemical pesticides use while maintaining crop health and productivity. Full article
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28 pages, 363 KiB  
Review
Biofilm Producing Methicillin-Resistant Staphylococcus aureus (MRSA) Infections in Humans: Clinical Implications and Management
Pathogens 2024, 13(1), 76; https://doi.org/10.3390/pathogens13010076 (registering DOI) - 15 Jan 2024
Abstract
Since its initial description in the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has developed multiple mechanisms for antimicrobial resistance and evading the immune system, including biofilm production. MRSA is now a widespread pathogen, causing a spectrum of infections ranging from superficial skin issues to [...] Read more.
Since its initial description in the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has developed multiple mechanisms for antimicrobial resistance and evading the immune system, including biofilm production. MRSA is now a widespread pathogen, causing a spectrum of infections ranging from superficial skin issues to severe conditions like osteoarticular infections and endocarditis, leading to high morbidity and mortality. Biofilm production is a key aspect of MRSA’s ability to invade, spread, and resist antimicrobial treatments. Environmental factors, such as suboptimal antibiotics, pH, temperature, and tissue oxygen levels, enhance biofilm formation. Biofilms are intricate bacterial structures with dense organisms embedded in polysaccharides, promoting their resilience. The process involves stages of attachment, expansion, maturation, and eventually disassembly or dispersion. MRSA’s biofilm formation has a complex molecular foundation, involving genes like icaADBC, fnbA, fnbB, clfA, clfB, atl, agr, sarA, sarZ, sigB, sarX, psm, icaR, and srtA. Recognizing pivotal genes for biofilm formation has led to potential therapeutic strategies targeting elemental and enzymatic properties to combat MRSA biofilms. This review provides a practical approach for healthcare practitioners, addressing biofilm pathogenesis, disease spectrum, and management guidelines, including advances in treatment. Effective management involves appropriate antimicrobial therapy, surgical interventions, foreign body removal, and robust infection control practices to curtail spread within healthcare environments. Full article
(This article belongs to the Special Issue Advances in Treatment of Biofilm Infections)
18 pages, 7154 KiB  
Article
Three New Species of Russulaceae (Russulales, Basidiomycota) from Southern China
J. Fungi 2024, 10(1), 70; https://doi.org/10.3390/jof10010070 (registering DOI) - 15 Jan 2024
Abstract
The characterization of natural fungal diversity impacts our understanding of ecological and evolutionary processes and can lead to novel bioproduct discovery. Russula and Lactarius, both in the order Russulales, represent two large genera of ectomycorrhizal fungi that include edible as well as [...] Read more.
The characterization of natural fungal diversity impacts our understanding of ecological and evolutionary processes and can lead to novel bioproduct discovery. Russula and Lactarius, both in the order Russulales, represent two large genera of ectomycorrhizal fungi that include edible as well as toxic varieties. Based on morphological and phylogenetic analyses, including nucleotide sequences of the internal transcribed spacer (ITS), the 28S large subunit of ribosomal RNA (LSU), the second largest subunit of RNA polymerase II (RPB2), the ribosomal mitochondrial small subunit (mtSSU), and the translation elongation factor 1-α (TEF1-α) gene sequences, we here describe and illustrate two new species of Russula and one new species of Lactarius from southern China. These three new species are: R. junzifengensis (R. subsect. Virescentinae), R. zonatus (R. subsect. Crassotunicatae), and L. jianyangensis (L. subsect. Zonarii). Full article
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11 pages, 1885 KiB  
Article
Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway
Toxics 2024, 12(1), 73; https://doi.org/10.3390/toxics12010073 (registering DOI) - 15 Jan 2024
Abstract
Ritonavir (RTV) is an antiviral and a component of COVID-19 treatments. Moreover, RTV demonstrates anti-cancer effects by suppressing AKT. However, RTV has cytotoxicity and suppresses sperm functions by altering AKT activity. Although abnormal AKT activity is known for causing detrimental effects on sperm [...] Read more.
Ritonavir (RTV) is an antiviral and a component of COVID-19 treatments. Moreover, RTV demonstrates anti-cancer effects by suppressing AKT. However, RTV has cytotoxicity and suppresses sperm functions by altering AKT activity. Although abnormal AKT activity is known for causing detrimental effects on sperm functions, how RTV alters AKT signaling in spermatozoa remains unknown. Therefore, this study aimed to investigate reproductive toxicity of RTV in spermatozoa through phosphoinositide 3-kinase/phosphoinositide-dependent protein kinase-1/protein kinase B (PI3K/PDK1/AKT) signaling. Duroc spermatozoa were treated with various concentrations of RTV, and capacitation was induced. Sperm functions (sperm motility, motion kinematics, capacitation status, and cell viability) and expression levels of tyrosine-phosphorylated proteins and PI3K/PDK1/AKT pathway-related proteins were evaluated. In the results, RTV significantly suppressed sperm motility, motion kinematics, capacitation, acrosome reactions, and cell viability. Additionally, RTV significantly increased levels of phospho-tyrosine proteins and PI3K/PDK1/AKT pathway-related proteins except for AKT and PI3K. The expression level of AKT was not significantly altered and that of PI3K was significantly decreased. These results suggest RTV may suppress sperm functions by induced alterations of PI3K/PDK1/AKT pathway through abnormally increased tyrosine phosphorylation. Therefore, we suggest people who use or prescribe RTV need to consider its male reproductive toxicity. Full article
(This article belongs to the Section Reproductive and Developmental Toxicity)
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24 pages, 5115 KiB  
Article
Neural Network Algorithm with Reinforcement Learning for Microgrid Techno-Economic Optimization
Mathematics 2024, 12(2), 280; https://doi.org/10.3390/math12020280 - 15 Jan 2024
Abstract
Hybrid energy systems (HESs) are gaining prominence as a practical solution for powering remote and rural areas, overcoming limitations of conventional energy generation methods, and offering a blend of technical and economic benefits. This study focuses on optimizing the sizes of an autonomous [...] Read more.
Hybrid energy systems (HESs) are gaining prominence as a practical solution for powering remote and rural areas, overcoming limitations of conventional energy generation methods, and offering a blend of technical and economic benefits. This study focuses on optimizing the sizes of an autonomous microgrid/HES in the Kingdom of Saudi Arabia, incorporating solar photovoltaic energy, wind turbine generators, batteries, and a diesel generator. The innovative reinforcement learning neural network algorithm (RLNNA) is applied to minimize the annualized system cost (ASC) and enhance system reliability, utilizing hourly wind speed, solar irradiance, and load behavior data throughout the year. This study validates RLNNA against five other metaheuristic/soft-computing approaches, demonstrating RLNNA’s superior performance in achieving the lowest ASC at USD 1,219,744. This outperforms SDO and PSO, which yield an ASC of USD 1,222,098.2, and MRFO, resulting in an ASC of USD 1,222,098.4, while maintaining a loss of power supply probability (LPSP) of 0%. RLNNA exhibits faster convergence to the global solution than other algorithms, including PSO, MRFO, and SDO, while MRFO, PSO, and SDO show the ability to converge to the optimal global solution. This study concludes by emphasizing RLNNA’s effectiveness in optimizing HES sizing, contributing valuable insights for off-grid energy systems in remote regions. Full article
(This article belongs to the Special Issue Modeling, Optimization and Algorithms for Power Systems)
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12 pages, 1811 KiB  
Article
Trap-Door Thoracotomy and Clamshell Thoracotomy as Surgical Approaches for Neuroblastoma and Other Thoracic Tumors in Children
Cancers 2024, 16(2), 373; https://doi.org/10.3390/cancers16020373 (registering DOI) - 15 Jan 2024
Abstract
Solid tumors of the cervicothoracic junction, the posterior mediastinum, or bilateral dorsal thoracic tumors represent a challenge in pediatric surgical oncology. The aim of this study was to evaluate trap-door thoracotomy and clamshell thoracotomy as surgical approaches. A single-center retrospective study of children [...] Read more.
Solid tumors of the cervicothoracic junction, the posterior mediastinum, or bilateral dorsal thoracic tumors represent a challenge in pediatric surgical oncology. The aim of this study was to evaluate trap-door thoracotomy and clamshell thoracotomy as surgical approaches. A single-center retrospective study of children with solid tumors in these specific localizations was performed. From 2015 to 2023, 26 children (17 girls; 9 boys) were treated at a median age of 54 months (range 8–229). Tumor resection was performed for neuroblastoma (n = 11); metastatic disease (n = 7); malignant rhabdoid tumor (n = 4); Ewing sarcoma (n = 1); inflammatory myofibroblastic tumor (n = 1); rhabdomyosarcoma (n = 1); and neurofibroma (n = 1). The surgical goal of macroscopic complete excision was achieved in all of the 14 children who underwent trap-door thoracotomy and in 11 of the 12 children who underwent clamshell thoracotomy. There were no major complications. At a median follow-up of 8 months (range 0–60), the disease was under local control or in complete remission in 66.7% of the children. In conclusion, surgical resection of solid tumors of the cervicothoracic junction in children can be performed safely and successfully with trap-door thoracotomy and with clamshell thoracotomy for posterior mediastinal or bilateral dorsal thoracic tumors. Full article
(This article belongs to the Special Issue Novel Treatments and Technologies Applied to Neuroblastoma)
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18 pages, 3909 KiB  
Article
Effects of Extreme-Ambient Temperatures in Silver Barb (Barbonymus gonionotus): Metabolic, Hemato-Biochemical Responses, Enzymatic Activity and Gill Histomorphology
Water 2024, 16(2), 292; https://doi.org/10.3390/w16020292 - 15 Jan 2024
Abstract
A global interest in Silver Barb (Barbonymus gonionotus) cultivation has arisen because of a combination of declining wild stock and a steady increase in demand and market value. The purpose of the current investigation was to evaluate the impact of extreme [...] Read more.
A global interest in Silver Barb (Barbonymus gonionotus) cultivation has arisen because of a combination of declining wild stock and a steady increase in demand and market value. The purpose of the current investigation was to evaluate the impact of extreme water temperature changes on growth, hemato-biochemical responses, pepsin enzyme activity and gill histomorphology of B. gonionotus. Four distinct temperatures (22, 26, 30 and 34 °C) were applied in the laboratory (22, 26, 30 and 34 °C) in triplicate glass aquariums (150 L each). At 30 and 22 °C, respectively, the highest and the lowest length and weight gain, specific, daily and relative growth rates were noted. At 30 °C the lowest FCR was recorded (1.42 ± 0.04). The values related to hematology and biochemistry were found to be within normal ranges; nevertheless, there was a notable variation in the parameters when the temperature changed. Hematological results revealed that RBC, HB, PLT, HCT and PMV levels were significantly higher in groups 30 °C with respect to others. It was evident that cold and heat shock stress was present due to the decline in hematocrit levels and rise in WBC values. Regarding the biochemical responses, the level of triglycerides, cholesterol, AP, Ca+, HDL, and HDL/LDL ratio increased significantly higher at 30 °C. Glucose, total protein, albumin, Na+, K+, Cl−1, AST, bilirubin, uric acid, and LDL levels were significantly higher at 22 °C compared to other temperatures. There was a higher pepsin activity between 26 and 30 °C while the digestive somatic index (IDS) was disproportionate. Histological examination demonstrated the well-shaped gill tissues at 26 and 30 °C compared to distinctive pathology in other temperature treatments. As an end note, the results of the experiment indicated that B. gonionotus should be cultured at 26–30 °C to maximize the overall productivity and the health condition of this economically important fish species. Full article
(This article belongs to the Special Issue Impact of Climate Changes on Marine Ecology and Fishes)
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4 pages, 200 KiB  
Editorial
Polymeric Nanoparticles for Biomedical Applications
Polymers 2024, 16(2), 249; https://doi.org/10.3390/polym16020249 (registering DOI) - 15 Jan 2024
Abstract
Polymeric nanoparticles (NPs), utilized extensively in biomedical applications, have received increasing interest in the preceding years and today represent an established part of the nanotechnology field [...] Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Biomedical Applications)
15 pages, 696 KiB  
Review
Epidemiology of Cefotaxime-Hydrolysing β-Lactamase-Producing Escherichia coli in Children with Diarrhoea Reported Globally between 2012 and 2022
Microorganisms 2024, 12(1), 171; https://doi.org/10.3390/microorganisms12010171 - 15 Jan 2024
Abstract
The global spread of cefotaxime-hydrolysing β-lactamase (CTX-M)-producing Escherichia coli (E. coli) and its associated impact on paediatric diarrhoeal treatment and management has become a public health concern. This review assessed surveillance studies on CTX-M-producing E. coli associated with diarrhoea in children [...] Read more.
The global spread of cefotaxime-hydrolysing β-lactamase (CTX-M)-producing Escherichia coli (E. coli) and its associated impact on paediatric diarrhoeal treatment and management has become a public health concern. This review assessed surveillance studies on CTX-M-producing E. coli associated with diarrhoea in children published between 2012 and 2022 globally. A total of thirty-eight studies were included for data analysis, categorised into continental regions, and tabulated. The majority (68%) of studies were conducted in Asian countries while few studies were conducted in Europe (11%) and Africa (18%), respectively. On the African continent, the majority (11%) of studies were conducted in Northern Africa while no studies were reported in East Africa. On the American continent, 3% of the studies were reported from South America. The studies included were classified into diarrheagenic E. coli (74%; 28/38) and faecal carriage (26%; 10/38). Of all the E. coli pathotypes associated with CTX-M production, EPEC was frequently reported. The prevalence of CTX-M-producing E. coli including the CTX-M-15-producing variants ranged between 1% and 94%. About 37% of the studies generalised the report as blaCTX-M-positive E. coli. The use of sequencing in characterising the CTX-M-producing E. coli was reported in only 32% of all the studies. This review provides information on the epidemiology of CTX-M-15-producing E. coli in paediatric diarrhoea and the extent to which surveillance is being performed. This is relevant in informing clinical practice for the management of diarrhoea as well as the design of future surveillance studies. Full article
(This article belongs to the Special Issue Virulence Factors and Antibiotic Resistance of Enterobacterales 2.0)
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16 pages, 2385 KiB  
Commentary
APOBEC Mutagenesis in Cancer Development and Susceptibility
Cancers 2024, 16(2), 374; https://doi.org/10.3390/cancers16020374 - 15 Jan 2024
Abstract
APOBEC cytosine deaminases are prominent mutators in cancer, mediating mutations in over 50% of cancers. APOBEC mutagenesis has been linked to tumor heterogeneity, persistent cell evolution, and therapy responses. While emerging evidence supports the impact of APOBEC mutagenesis on cancer progression, the understanding [...] Read more.
APOBEC cytosine deaminases are prominent mutators in cancer, mediating mutations in over 50% of cancers. APOBEC mutagenesis has been linked to tumor heterogeneity, persistent cell evolution, and therapy responses. While emerging evidence supports the impact of APOBEC mutagenesis on cancer progression, the understanding of its contribution to cancer susceptibility and malignant transformation is limited. We examine the existing evidence for the role of APOBEC mutagenesis in carcinogenesis on the basis of the reported associations between germline polymorphisms in genes encoding APOBEC enzymes and cancer risk, insights into APOBEC activities from sequencing efforts of both malignant and non-malignant human tissues, and in vivo studies. We discuss key knowledge gaps and highlight possible ways to gain a deeper understanding of the contribution of APOBEC mutagenesis to cancer development. Full article
(This article belongs to the Special Issue The Study of Cancer Susceptibility Genes (Volume II))
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